Tuning the density profile of surface-grafted hyaluronan and the effect of counter-ions
2013 (English)In: European Physical Journal E, ISSN 1292-8941, Vol. 36, no 7, 70- p.Article in journal (Refereed) Published
The present paper investigates the structure and composition of grafted sodium hyaluronanat a solid-liquid interface using neutron reflection. The solvated polymer at the surface could be described with a density profile that decays exponentially towards the bulk solution. The density profileof the polymer varied depending on the deposition protocol. A single-stage deposition resulted in denser polymer layers, while layers created with a two-stage deposition process were more diffuse and had an overall lower density. Despite the diffuse density profile, two-stage deposition leads to a highersurface excess. Addition of calcium ions causes a strong collapse of the sodium hyaluronan chains, increasing the polymer density near the surface. This effect is more pronounced on the sample prepared by two-stage deposition due to the initial less dense profile. This study provides an understanding at a molecular level of how surface functionalization alters the structure and howsurface layers respond to changes in calcium ions in the solvent.
Place, publisher, year, edition, pages
2013. Vol. 36, no 7, 70- p.
Polymer Technologies Polymer Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-197814DOI: 10.1140/epje/i2013-13070-7ISI: 000322872700002OAI: oai:DiVA.org:uu-197814DiVA: diva2:614347