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Cortical thickness alterations in social anxiety disorder
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
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2013 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 536, 52-55 p.Article in journal (Refereed) Published
Abstract [en]

Social anxiety disorder (SAD) has been associated with aberrant processing of socio-emotional stimuli and failure to adaptively regulate emotion, corroborated by functional neuroimaging studies. However, only a few studies of structural brain abnormalities in SAD have been reported, and among these only one investigated cortical thickness. In the present study we used magnetic resonance imaging (MRI) in conjunction with an automated method to measure cortical thickness in patients with SAD (n=14) and healthy controls (n=12). Results showed significantly increased thickness of the left inferior temporal cortex in SAD patients relative to controls. Within the patient group, a negative association was found between social anxiety symptom severity and thickness of the right rostral anterior cingulate cortex. The observed alterations in brain structure may help explain previous findings of dysfunctional regulation and processing of emotion in SAD.

Place, publisher, year, edition, pages
2013. Vol. 536, 52-55 p.
Keyword [en]
Social phobia, Gray matter, Morphological, fMRI, Brain imaging, Cortical thickness
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-197990DOI: 10.1016/j.neulet.2012.12.060ISI: 000315834200011OAI: oai:DiVA.org:uu-197990DiVA: diva2:615003
Available from: 2013-04-08 Created: 2013-04-08 Last updated: 2013-04-08Bibliographically approved

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Frick, AndreasFurmark, Tomas
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