uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Determinants of Cardiovascular Risk in Haemodialysis Patients: Post hoc Analyses of the AURORA Study
Show others and affiliations
2013 (English)In: American Journal of Nephrology, ISSN 0250-8095, E-ISSN 1421-9670, Vol. 37, no 2, 144-151 p.Article in journal (Refereed) Published
Abstract [en]

Background: Haemodialysis patients are at high risk for cardiovascular (CV) events. The aim of the current study was to characterise the role of traditional and uraemia-specific CV risk factors in this patient population. Methods: A post hoc analysis of the AURORA trial which enrolled 2,776 haemodialysis patients from 280 centres and had a mean follow-up period of 3.2 years. Determinants of CV endpoints (time to major cardiovascular event (MACE), cardiac event, CV death) were identified by univariate Cox regression analysis. Subsequently, independent determinants were identified by multivariate regression analysis. Results: For the primary endpoint MACE (myocardial infarction, stroke and cardiac death), multivariate analysis revealed that independent determinants were: age (hazard ratio (HR) 1.03 per year), serum phosphate level (HR 1.50 per mmol/l), albumin level (HR 0.94 per gip, years on haemodialysis (HR 1.03 per year), diabetes mellitus (HR 1.38), preexisting coronary heart disease (HR 1.54) and C-reactive protein (CRP) level (HR 1.14 per mg/l). However, conventional risk factors such as smoking, dyslipidaemia, systolic and diastolic blood pressure and pulse pressure had no significant effect. Conclusions: Although we identify CRP, low albumin, and high phosphorus as risk factors for MACE, lowering CRP did not influence MACE outcomes in our trial. Caution is therefore warranted in implying risk factors being causal in end-stage renal disease.

Place, publisher, year, edition, pages
2013. Vol. 37, no 2, 144-151 p.
Keyword [en]
Cardiovascular events, Haemodialysis, Epidemiology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-198063DOI: 10.1159/000346710ISI: 000315978200008OAI: oai:DiVA.org:uu-198063DiVA: diva2:615211
Available from: 2013-04-09 Created: 2013-04-08 Last updated: 2013-04-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Fellström, Bengt C.
By organisation
Renal Medicine
In the same journal
American Journal of Nephrology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 195 hits
ReferencesLink to record
Permanent link

Direct link