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Prognostic relevance of PCI-related myocardial infarction
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
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2013 (English)In: Nature Reviews Cardiology, ISSN 1759-5002, Vol. 10, no 4, 231-236 p.Article in journal (Refereed) Published
Abstract [en]

Procedure-related myocardial infarction (pMI) is directly associated with a coronary revascularization procedure, such as percutaneous coronary intervention (PCI) or CABG surgery. In contrast to spontaneous myocardial infarction (MI), the prognostic relevance of pMI is the subject of ongoing debate. Data from retrospective analyses of large, randomized clinical trials, and large, contemporary cohort studies have several shortcomings that limit their extrapolation to clinical practice. In our opinion, the currently available evidence is insufficient to conclude that pMI during PCI, as currently defined, always has important prognostic implications. Until further evidence is available, we recommend adopting the definition for MI given in the third universal definition of MI, which differentiates between pMI and spontaneous MI. This is important not only for clinical decision-making but also for the interpretation of pMI as a surrogate end point in clinical trials. Further studies are essential to understand the pathophysiology and consequences of pMI.

Place, publisher, year, edition, pages
2013. Vol. 10, no 4, 231-236 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-198288DOI: 10.1038/nrcardio.2013.19ISI: 000316566900008PubMedID: 23438686OAI: oai:DiVA.org:uu-198288DiVA: diva2:615688
Available from: 2013-04-11 Created: 2013-04-11 Last updated: 2013-04-22Bibliographically approved

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Wallentin, Lars
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