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The alpha(2)-Adrenoceptor Antagonist Yohimbine Normalizes Increased Islet Blood Flow in GK Rats: A Model of Type 2 Diabetes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2013 (English)In: Hormone and Metabolic Research, ISSN 0018-5043, E-ISSN 1439-4286, Vol. 45, no 3, 252-254 p.Article in journal (Refereed) Published
Abstract [en]

Overexpression of alpha(2A)-adrenoceptors contributes to type 2 diabetes in GK rats. We aimed to investigate if alpha(2)-adrenoceptor inhibition affected islet blood flow in these rats. Anesthetized GK and Wistar-F rats were given the alpha(2)-adrenoceptor inhibitor yohimbine (2.5 mg/kg BW) intravenously. The GK rats had higher blood glucose and serum insulin concentrations than WF rats. Yohimbine affected neither of these values in WF rats, but decreased blood glucose and increased serum insulin concentrations in GK rats. Total pancreatic and islet blood flows, measured with microspheres, were increased in GK when compared to WF rats. Yohimbine affected none of the blood flow values in WF rats, whereas islet blood flow in GK rats was reduced to values similar to those seen in WF rats. Overexpression of alpha(2)-adrenoceptors may contribute to the increased islet blood flow seen in GK rats, and may be eligible for pharmacologic intervention.

Place, publisher, year, edition, pages
2013. Vol. 45, no 3, 252-254 p.
National Category
Natural Sciences Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-198395DOI: 10.1055/s-0032-1323843ISI: 000316185700011OAI: oai:DiVA.org:uu-198395DiVA: diva2:616155
Available from: 2013-04-15 Created: 2013-04-15 Last updated: 2017-12-06Bibliographically approved

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Sandberg, MonicaPettersson, UlrikaJansson, Leif

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