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Relationship of 6-desaturase and 5-desaturase activities with thyroid hormone status in adolescents with eating disorders and weight loss
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. (Barnendokrinologisk forskning/Gustafsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
2013 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 102, no 4, 416-418 p.Article in journal (Refereed) Published
Abstract [en]

Aim In starvation, there is down-regulation of metabolism and changes in essential fatty acid (FA) status, which could be related to alterations of desaturase activities. Presently, the relationship between thyroid hormones and desaturase activities has been investigated in adolescents with eating disorders and weight loss. Methods Serum triiodothyronine concentrations and proportions of polyunsaturated FA in plasma phospholipids were analysed in blood samples from 227 adolescents with ED. 6-desaturase (D6D) activity was calculated as the FA ratio 20:36/18:26 and 5-desaturase (D5D) activity as the ratio 20:46/20:36. Results Serum triiodothyronine concentrations were related to leanness and ongoing weight loss. The estimated D6D activity was positively correlated with serum triiodothyronine (R2=0.232; p<0.001). D5D activity exhibited a strong inverse correlation with serum triiodothyronine (R2=0.410; p<0.001). Conclusion Changes in desaturase activities during starvation cannot be explained by inhibition/disinhibition by essential FA only. It is possible that the effects of starvation on these enzyme activities, and hence on essential FA status, are mediated by triiodothyronine.

Place, publisher, year, edition, pages
2013. Vol. 102, no 4, 416-418 p.
Keyword [en]
Desaturase, Eating disorder, PUFA, Triiodothyronine
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-198598DOI: 10.1111/apa.12132ISI: 000316325400031OAI: oai:DiVA.org:uu-198598DiVA: diva2:617466
Available from: 2013-04-23 Created: 2013-04-22 Last updated: 2017-12-06Bibliographically approved

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Swenne, IngemarVessby, Bengt

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