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A combined test of acetylcholine-mediated vasodilation of both the forearm resistance vessels and the radial artery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
2013 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 33, no 3, 206-210 p.Article in journal (Refereed) Published
Abstract [en]

Objective To evaluate a new combined test of endothelium-dependent vasodilation (EDV) in the forearm resistance vessel and the radial artery. Methods Acetylcholine (ACh) and sodium nitroprusside (SNP) infusion in the brachial artery were used to simultaneous evaluate EDV and endothelium-independent vasodilation (EIDV) in forearm resistance vessels (plethysmography) and in the radial artery (ultrasound) in 76 healthy subjects. Brachial artery ultrasound was used to assess flow-mediated vasodilation (FMD). Results Acetylcholine induced a 4 center dot 5% (median value, P=0 center dot 0010) increase in the radial artery diameter, while SNP induced a 31 center dot 2% increase in diameter (P<0 center dot 0001). While no increase in radial artery blood flow was induced by ACh (P=0 center dot 69), an increase by 181% in radial blood flow was induced by SNP (P<0 center dot 0001). When relating the radial artery diameter data to FMD, the change in radial artery diameter induced by ACh was significantly correlated with FMD (r=0 center dot 35, P=0 center dot 013). No such relationship was seen for the diameter change induced by SNP (r=0 center dot 03, P=0 center dot 81). When relating the radial artery blood flow data to EDV and EIDV, the change in radial artery blood flow induced by ACh was significantly correlated with EDV in an inverse fashion (r=0 center dot 42, P=0 center dot 0032). No such relationship was seen for the blood flow change induced by SNP when related to EIDV (r=0 center dot 07, P=0 center dot 63). Conclusion Simultaneous measurements of blood flow in forearm vessels by plethysmography and in the radial artery by ultrasound during ACh infusion is a new way to assess EDV in both resistance and conduit arteries during one investigation.

Place, publisher, year, edition, pages
2013. Vol. 33, no 3, 206-210 p.
Keyword [en]
acetylcholine, brachial artery, endothelium, ultrasound, vasodilation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-198593DOI: 10.1111/cpf.12014ISI: 000316692300006OAI: oai:DiVA.org:uu-198593DiVA: diva2:617536
Available from: 2013-04-23 Created: 2013-04-22 Last updated: 2017-12-06Bibliographically approved

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