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Mammography casting-type calcification and risk of local recurrence in DCIS: analyses from a randomised study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2013 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 108, no 4, 812-819 p.Article in journal (Refereed) Published
Abstract [en]

Background: We studied the association between mammographic calcifications and local recurrence in the ipsilateral breast. Methods: Case-cohort study within a randomised trial of radiotherapy in breast conservation for ductal cancer in situ of the breast (SweDCIS). We studied mammograms from cases with an ipsilateral breast event (IBE) and from a subcohort randomly sampled at baseline. Lesions were classified as a density without calcifications, architectural distortion, powdery, crushed stone-like or casting-type calcifications. Results: Calcifications representing necrosis were found predominantly in younger women. Women with crushed stone or casting-type microcalcifications had higher histopathological grade and more extensive disease. The relative risk (RR) of a new IBE comparing those with casting-type calcifications to those without calcifications was 2.10 (95% confidence interval (Cl) 0.92-4.80). This risk was confined to in situ recurrences; the RR of an IBE associated with casting-type calcifications on the mammogram adjusted for age and disease extent was 16.4 (95% Cl 2.20-140). Conclusion: Mammographic appearance of ductal carcinoma in situ of the breast is prognostic for the risk of an in situ IBE and may also be an indicator of responsiveness to RT in younger women.

Place, publisher, year, edition, pages
2013. Vol. 108, no 4, 812-819 p.
Keyword [en]
DCIS, ipsilateral recurrence, mammographic calcifications, radiotherapy, breast-conserving surgery, randomised trial
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-198921DOI: 10.1038/bjc.2013.26ISI: 000316775900011OAI: oai:DiVA.org:uu-198921DiVA: diva2:619129
Available from: 2013-05-02 Created: 2013-04-29 Last updated: 2013-05-02Bibliographically approved

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Holmberg, Lars
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Endocrine SurgeryDepartment of Medical Sciences
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