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Reference values for fasting insulin in 75 year old females and males
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemical endocrinology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
2013 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 46, no 12, 1125-1127 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES:

Reference intervals for insulin are often based on fairly small study groups with unknown body mass index (BMI). They are also much younger than most patients seeking care. These values are not optimal for elderly patients, as many biological markers change over time and adequate reference intervals are important for correct clinical decisions.

DESIGN AND METHODS:

We studied fasting insulin (f-insulin) values in a cohort of 698 75-year old non-diabetic males and females. The 2.5th and 97.5th percentiles for all individuals, males and females were calculated according to the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference intervals.

RESULTS:

There was a strong positive correlation between BMI and f-insulin, which led to the calculation of separate reference intervals for individuals with BMI ≤30.

CONCLUSIONS:

The reference interval for f-insulin for all study subjects was 1.74-18.27mIU/L and for individuals with BMI ≤30 (n=574) the reference interval was 1.66-15.05mIU/L.

Place, publisher, year, edition, pages
2013. Vol. 46, no 12, 1125-1127 p.
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:uu:diva-199016DOI: 10.1016/j.clinbiochem.2013.03.024ISI: 000322424900029PubMedID: 23578739OAI: oai:DiVA.org:uu-199016DiVA: diva2:619201
Available from: 2013-05-02 Created: 2013-05-02 Last updated: 2017-12-06Bibliographically approved

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Larsson, AndersStridsberg, MatsLind, Lars

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