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Controlled ovarian hyperstimulation for IVF: impact on ovarian, endometrial and cervical cancer-a systematic review and meta-analysis
Assisted Reproduction Unit, 3rd Department of Obstetrics and Gynecology, University of Athens, Attikon Hospital, Chaidari, Greece.
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Greece.
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Greece.
UK Cochrane Centre, National Institute of Health Research, Oxford University Hospitals, UK.
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2013 (English)In: Human Reproduction Update, ISSN 1355-4786, E-ISSN 1460-2369, Vol. 19, no 2, 105-123 p.Article, review/survey (Refereed) Published
Abstract [en]

BACKGROUND: In response to the ongoing debate on the long-term effects of assisted reproduction technologies, such as IVF, we systematically reviewed and meta-analyzed available evidence on the association between controlled ovarian hyperstimulation for IVF and risk of ovarian, endometrial and cervical cancer. METHODS: Eligible studies were identified and pooled effect estimates for relative risk (RR) were calculated by cancer type among two reference groups (general population or infertile women), through fixed-or random-effects models as appropriate. RESULTS: Nine cohort studies were synthesized, corresponding to a total size of 109 969 women exposed to IVF, among whom 76 incident cases of ovarian, 18 of endometrial and 207 cases of cervical cancer were studied. The synthesis of studies with general population as the reference group pointed to a statistically significant positive association between IVF and increased risk for ovarian (RR = 1.50, 95% confidence interval (CI): 1.17-1.92) and endometrial (RR = 2.04, 95% CI: 1.22-3.43), but not cervical (RR = 0.86, 95% CI: 0.49-1.49)cancers. On the contrary, when infertile women were used as the reference group, no significant associations with ovarian, endometrial or cervical cancer types were noted (RR=1.26, 95% CI: 0.62-2.55 RR=0.45, 95% CI: 0.18-1.14 and RR= 5.70, 95% CI: 0.28-117.20, respectively). CONCLUSIONS: IVF does not seem to be associated with elevated cervical cancer risk, nor with ovarian or endometrial cancer when the confounding effect of infertility was neutralized in studies allowing such comparisons. Of note, only one study provided follow-up longer than 10 years for the group exposed to IVF. Future cohort studies should preferably use infertile women as the reference group, rely on IVF-registered valid exposure data, adjust for a variety of meaningful confounders and adopt relatively longer follow-up periods before sound conclusions are drawn.

Place, publisher, year, edition, pages
2013. Vol. 19, no 2, 105-123 p.
Keyword [en]
ovarian cancer, endometrial cancer, cervical cancer, infertility, IVF
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-199045DOI: 10.1093/humupd/dms051ISI: 000316711800003OAI: oai:DiVA.org:uu-199045DiVA: diva2:619306
Available from: 2013-05-02 Created: 2013-05-02 Last updated: 2016-06-21Bibliographically approved

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Skalkidou, Alkistis
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