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The frequency of an IL-18-associated haplotype in Africans
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
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2013 (English)In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 21, no 4, 465-468 p.Article in journal (Refereed) Published
Abstract [en]

Variation within the gene for the proinflammatory cytokine interleukin (IL)-18 has been associated with inter-individual differences in levels of free protein and disease risk. We investigated the frequency of function-associated IL18 gene haplotypes in an extensive sample (n=2357) of African populations from across the continent. A previously identified five tagging SNP (single-nucleotide polymorphism) haplotype (here designated hGTATA), known to be associated with lower levels of IL-18, was observed at a frequency of 27% in a British population of recent European ancestry, but was found at low frequency (<8%) or completely absent in African populations. Potentially protective variants may, as a consequence, be found at low frequency in African individuals and may confer a difference in disease risk.

Place, publisher, year, edition, pages
2013. Vol. 21, no 4, 465-468 p.
Keyword [en]
IL-18, atherosclerosis, genetic diversity, Africa
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-199715DOI: 10.1038/ejhg.2012.184ISI: 000317089300020OAI: oai:DiVA.org:uu-199715DiVA: diva2:621088
Available from: 2013-05-13 Created: 2013-05-13 Last updated: 2013-05-13Bibliographically approved

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