Antimicrobial activity of fibrinogen and fibrinogen-derived peptides: a novel link between coagulation and innate immunity
2013 (English)In: Thrombosis and Haemostasis, ISSN 0340-6245, Vol. 109, no 5, 930-939 p.Article in journal (Refereed) Published
Fibrinogen is a key player in the blood coagulation system, and is upon activation with thrombin converted into fibrin that subsequently forms a fibrin clot. In the present study, we investigated the role of fibrinogen in the early innate immune response. Here we show that the viability of fibrinogen-binding bacteria is affected in human plasma activated with thrombin. Moreover, we found that the peptide fragment GHR28 released from the β-chain of fibrinogen has antimicrobial activity against bacteria that bind fibrinogen to their surface, whereas non-binding strains are unaffected. Notably, bacterial killing was detected in Group A Streptococcus bacteria entrapped in a fibrin clot, suggesting that fibrinogen and coagulation is involved in the early innate immune system to quickly wall off and neutralise invading pathogens.
Place, publisher, year, edition, pages
2013. Vol. 109, no 5, 930-939 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-199878DOI: 10.1160/TH12-10-0739PubMedID: 23467586OAI: oai:DiVA.org:uu-199878DiVA: diva2:621780