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Association of serum calcium with serum sex steroid hormones in men in NHANES III
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
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2013 (English)In: The Aging Male, ISSN 1368-5538, E-ISSN 1473-0790, Vol. 16, no 4, 151-158 p.Article, review/survey (Refereed) Published
Abstract [en]


Bone is a positive regulator of male fertility, which indicates a link between regulation of bone remodeling and reproduction or more specifically a link between calcium and androgens. This possibly suggests how calcium is linked to prostate cancer development through its link with the reproductive system. We studied serum calcium and sex steroid hormones in the Third National Health and Nutrition Examination Survey (NHANES III).


Serum calcium and sex steroid hormones were measured for 1262 men in NHANES III. We calculated multivariable-adjusted geometric means of serum concentrations of total and estimated free testosterone and estradiol, androstanediol glucuronide (AAG), and sex hormone binding globulin (SHBG) by categories of calcium (lowest 5% [<1.16 mmol/L], mid 90%, top 5% [≥1.30 mmol/L]).


Levels of total and free testosterone, total estradiol or AAG did not differ across categories of serum calcium. Adjusted SHBG concentrations were 36.4 for the bottom 5%, 34.2 for the mid 90% and 38.9 nmol/L for the top 5% of serum calcium (Ptrend = 0.006), free estradiol levels were 0.88, 0.92 and 0.80 pg/ml (Ptrend = 0.048).


This link between calcium and sex steroid hormones, in particular the U-shaped pattern with SHBG, may, in part, explain why observational studies have found a link between serum calcium and risk of prostate cancer.

Place, publisher, year, edition, pages
2013. Vol. 16, no 4, 151-158 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-199914DOI: 10.3109/13685538.2013.772133ISI: 000327505800002PubMedID: 23672276OAI: oai:DiVA.org:uu-199914DiVA: diva2:621808
Available from: 2013-05-17 Created: 2013-05-17 Last updated: 2014-01-05Bibliographically approved

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