uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
Show others and affiliations
2013 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 108, 2321-2328 p.Article in journal (Refereed) Published
Abstract [en]


Membranous expression of the anti-adhesive glycoprotein podocalyxin-like (PODXL) has previously been found to correlate with poor prognosis in several major cancer forms. Here we examined the prognostic impact of PODXL expression in urothelial bladder cancer.


Immunohistochemical PODXL expression was examined in tissue microarrays with tumours from two independent cohorts of patients with urothelial bladder cancer: n=100 (Cohort I) and n=343 (Cohort II). The impact of PODXL expression on disease-specific survival (DSS; Cohort II), 5-year overall survival (OS; both cohorts) and 2-year progression-free survival (PFS; Cohort II) was assessed.


Membranous PODXL expression was significantly associated with more advanced tumour (T) stage and high-grade tumours in both cohorts, and a significantly reduced 5-year OS (unadjusted HR=2.25 in Cohort I and 3.10 in Cohort II, adjusted HR=2.05 in Cohort I and 2.18 in Cohort II) and DSS (unadjusted HR=4.36, adjusted HR=2.70). In patients with Ta and T1 tumours, membranous PODXL expression was an independent predictor of a reduced 2-year PFS (unadjusted HR=6.19, adjusted HR=4.60) and DSS (unadjusted HR=8.34, adjusted HR=7.16).


Membranous PODXL expression is an independent risk factor for progressive disease and death in patients with urothelial bladder cancer.

Place, publisher, year, edition, pages
2013. Vol. 108, 2321-2328 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-199936DOI: 10.1038/bjc.2013.215ISI: 000320249500016PubMedID: 23652315OAI: oai:DiVA.org:uu-199936DiVA: diva2:621821
Available from: 2013-05-17 Created: 2013-05-17 Last updated: 2013-07-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Segersten, UlrikaMalmström, Per-Uno
By organisation
In the same journal
British Journal of Cancer
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 295 hits
ReferencesLink to record
Permanent link

Direct link