uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effect of gene, environment and maternal depressive symptoms on pre-adolescence behavior problems: a longitudinal study
Linkoping Univ, Fac Hlth Sci, IKE, Div Child & Adolescent Psychiat, S-58185 Linkoping, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
Linkoping Univ, Div Obstet & Gynecol IKE, Fac Hlth Sci, S-58185 Linkoping, Sweden.
Linkoping Univ, Div Obstet & Gynecol IKE, Fac Hlth Sci, S-58185 Linkoping, Sweden.
Show others and affiliations
2013 (English)In: Child and Adolescent Psychiatry and Mental Health, ISSN 1753-2000, E-ISSN 1753-2000, Vol. 7, 10Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Depression is a common and disabling condition with a high relapse frequency. Maternal mental health problems and experience of traumatic life events are known to increase the risk of behavior problems in children. Recently, genetic factors, in particular gene-by-environment interaction models, have been implicated to explain depressive etiology. However, results are inconclusive.

METHODS:

Study participants were members of the SESBiC-study. A total of 889 mothers and their children were followed during the child's age of 3 months to 12 years. Information on maternal depressive symptoms was gathered postpartum and at a 12 year follow-up. Mothers reported on child behavior and traumatic life events experienced by the child at age 12. Saliva samples were obtained from children for analysis of 5-HTTLPR and BDNF Val66Met polymorphisms.

RESULTS:

Multivariate analysis showed a significant association between maternal symptoms of depression and anxiety, and internalizing problems in 12-year-old children (OR 5.72, 95% CI 3.30-9.91). Furthermore, carriers of two short alleles (s/s) of the 5-HTTLPR showed a more than 4-fold increased risk of internalizing problems at age 12 compared to l/l carriers (OR 4.73, 95% CI 2.14-10.48). No gene-by-environment interaction was found and neither depressive symptoms postpartum or traumatic experiences during childhood stayed significant in the final model.

CONCLUSIONS:

Concurrent maternal symptoms of depression and anxiety are significant risk factors for behavior problems in children, which need to be taken into account in clinical practice. Furthermore, we found a main effect of 5-HTTLPR on internalizing symptoms in 12-year-old children, a finding that needs to be confirmed in future studies.

Place, publisher, year, edition, pages
2013. Vol. 7, 10
Keyword [en]
Child, Depression, 5-HTTLPR, BDNF, Longitudinal, SESBiC-study
National Category
Pediatrics Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-200314DOI: 10.1186/1753-2000-7-10ISI: 000209640300009PubMedID: 23518193OAI: oai:DiVA.org:uu-200314DiVA: diva2:623209
Funder
Swedish Research Council
Available from: 2013-05-25 Created: 2013-05-25 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

fulltext(491 kB)114 downloads
File information
File name FULLTEXT01.pdfFile size 491 kBChecksum SHA-512
60b4ed21186e74a97d0e47b23694a851588730f91361bd9754f6493fb69f920bd6823b0f29c63a346589ad3339192364e0d7ff88c993ce9c297f64ec4b6f44e6
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Comasco, ErikaOreland, Lars

Search in DiVA

By author/editor
Comasco, ErikaOreland, Lars
By organisation
Neuro-psycho-pharmacology
In the same journal
Child and Adolescent Psychiatry and Mental Health
PediatricsPsychiatry

Search outside of DiVA

GoogleGoogle Scholar
Total: 114 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 871 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf