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Combined Food and Micronutrient Supplements during Pregnancy Have Limited Impact on Child Blood Pressure and Kidney Function in Rural Bangladesh
Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK.
Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
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2013 (English)In: Journal of Nutrition, ISSN 0022-3166, E-ISSN 1541-6100, Vol. 143, no 5, 728-734 p.Article in journal (Refereed) Published
Abstract [en]

Observational evidence suggests nutritional exposures during in utero development may have long-lasting consequences for health; data from interventions are scarce. Here, we present a trial follow-up study to assess the association between prenatal food and micronutrient supplementation and childhood blood pressure and kidney function. During the MINIMat Trial in rural Bangladesh, women were randomly assigned early in pregnancy to receive an early or later invitation to attend a food supplementation program and additionally to receive either iron and folate or multiple micronutrient tablets daily. The 3267 singleton birth individuals with measured anthropometry born during the trial were eligible for a follow-up study at 4.5 y old. A total of 77% of eligible individuals were recruited and blood pressure, kidney size by ultrasound, and glomerular filtration rate (GFR; calculated from plasma cystatin c) were assessed. In adjusted analysis, early invitation to food supplementation was associated with a 0.72-mm Hg [(95% CI: 0.16, 1.28); P = 0.01] lower childhood diastolic blood pressure and maternal MMS supplementation was associated with a marginally higher [0.87 mm Hg (95% CI: 0.18, 1.56); P = 0.01] childhood diastolic blood pressure. There was also some evidence that a supplement higher in iron was associated with a higher offspring GFR. No other effects of the food or micronutrient interventions were observed and there was no interaction between the interventions on the outcomes studied. These marginal associations and small effect sizes suggest limited public health importance in early childhood.

Place, publisher, year, edition, pages
2013. Vol. 143, no 5, 728-734 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-200672DOI: 10.3945/jn.112.168518ISI: 000318056700024OAI: oai:DiVA.org:uu-200672DiVA: diva2:624925
Available from: 2013-06-03 Created: 2013-06-03 Last updated: 2013-07-18Bibliographically approved

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Persson, Lars-Åke
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