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Identification and expression of stressosomal proteins in Mycobacterium marinum under various growth and stress conditions
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Chemical Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Chemical Biology.
School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
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2013 (English)In: FEMS Microbiology Letters, ISSN 0378-1097, E-ISSN 1574-6968, Vol. 342, no 2, 98-105 p.Article in journal (Refereed) Published
Abstract [en]

Like other bacteria, Mycobacterium spp. have developed different strategies in response to environmental changes such as nutrient limitations and other different stress situations. We have identified candidate genes (rsb genes) from Mycobacterium marinum involved in the regulation of the activity of the alternative sigma factor, sigma F. This is a homolog of the master regulator of general stress response, sigma B, and the sporulation-specific sigma factor, sigma F, in Bacillus subtilis. The organization of these genes in M.marinum and B.subtilis is similar. Transcriptome and qRT-PCR data show that these genes are indeed expressed in M.marinum and that the levels of expression vary with growth phase and exposure to stress. In particular, cold stress caused a significant rise in the expression of all identified rsb and sigF genes. We discuss these data in relation to what is currently known for other Mycobacterium spp.

Place, publisher, year, edition, pages
2013. Vol. 342, no 2, 98-105 p.
Keyword [en]
Mycobacterium marinum, transcriptome analysis, stress proteins
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-200667DOI: 10.1111/1574-6968.12118ISI: 000318171000004OAI: oai:DiVA.org:uu-200667DiVA: diva2:624947
Available from: 2013-06-03 Created: 2013-06-03 Last updated: 2017-12-06Bibliographically approved

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Pettersson, B. M. FredrikNitharwal, Ram GopalDas, SarbashisBehra, Krishna P. R.Dasgupta, SantanuKirsebom, Leif A.

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Pettersson, B. M. FredrikNitharwal, Ram GopalDas, SarbashisBehra, Krishna P. R.Dasgupta, SantanuKirsebom, Leif A.
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