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Prognostic Factors for 12 Month Major Molecular Response for Patients with Chronic Myeloid Leukemia
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
2013 (English)Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Chronic Myeloid Leukemia is a kind of blood cancer with around 1 incidence per 100 000 persons/year. After the development of an effective treatment, imatinib, in the late 1990:s, the survival percentage has increased drastically. The high survival has turned the attention to different kinds of treatment responses, which in turn are good prognostic factors to future health status. In this thesis, the focus is on whether or not the patient has achieved a so called major molecular response after 12 month, or not. More precisely, the aim is to find prognostic factors to the 12 month response.

In order to find prognostic factors for this binary response variable, a multivariate logistic regression analysis is conducted, with the goal of finding a parsimonious logistic model that describes the data. The analysis is done from a merged dataset from three earlier studies. The prognostic factors in the final model are treatment, 3 month response, and enlarged spleen. However, the residual analysis indicates that the model is incomplete, implying that further research needs to be done.

Place, publisher, year, edition, pages
2013. , 39 p.
Keyword [en]
Chronic Myeloid Leukemia, CML, Major Molecular Response, MMR, Prognostic factors, Logistic regression, Statistical modelling
National Category
Other Social Sciences not elsewhere specified
URN: urn:nbn:se:uu:diva-201419OAI: oai:DiVA.org:uu-201419DiVA: diva2:627142
Subject / course
Educational program
Master Programme in Statistics
Available from: 2013-06-25 Created: 2013-06-11 Last updated: 2013-06-25Bibliographically approved

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