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WhichCyp: Prediction of Cytochromes P450 Inhibition
University of Copenhagen.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-8083-2864
University of Copenhagen.
2013 (English)In: Bioinformatics, ISSN 1367-4803, E-ISSN 1460-2059, Vol. 29, no 16, 2051-2052 p.Article in journal (Refereed) Published
Abstract [en]

SUMMARY: In this work we present WhichCyp, a tool for prediction of which cytochromes P450 isoforms (among 1A2, 2C9, 2C19, 2D6 and 3A4) a given molecule is likely to inhibit. The models are built from experimental high-throughput data using support vector machines and molecular signatures.

AVAILABILITY: The WhichCyp server is freely available for use on the web at http://drug.ku.dk/whichcyp, where the WhichCyp Java program and source code is also available for download.

CONTACT: pry@sund.ku.dk

SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Place, publisher, year, edition, pages
2013. Vol. 29, no 16, 2051-2052 p.
National Category
Bioinformatics and Systems Biology Bioinformatics (Computational Biology)
Research subject
URN: urn:nbn:se:uu:diva-202123DOI: 10.1093/bioinformatics/btt325ISI: 000322337400020PubMedID: 23740742OAI: oai:DiVA.org:uu-202123DiVA: diva2:630991
eSSENCE - An eScience CollaborationSwedish Research Council, 2011-6129
Available from: 2013-06-19 Created: 2013-06-19 Last updated: 2013-09-02Bibliographically approved

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Publisher's full textPubMedhttp://bioinformatics.oxfordjournals.org/content/29/16/2051.long

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