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Hippocampal volume in relation to clinical and cognitive outcome after electroconvulsive therapy in depression
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
2014 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 129, no 4, 303-311 p.Article in journal (Refereed) Published
Abstract [en]


In a previous magnetic resonance imaging (MRI) study, we found a significant increase in hippocampal volume immediately after electroconvulsive therapy (ECT) in patients with depression. The aim of this study was to evaluate hippocampal volume up to 1 year after ECT and investigate its possible relation to clinical and cognitive outcome.


Clinical and cognitive outcome in 12 in-patients with depression receiving antidepressive pharmacological treatment referred for ECT were investigated with the Montgomery-Asberg Depression Rating Scale (MADRS) and a broad neuropsychological test battery within 1 week before and after ECT. The assessments were repeated 6 and 12 months after baseline in 10 and seven of these patients, respectively. Hippocampal volumes were measured on all four occasions with 3 Tesla MRI.


Hippocampal volume returned to baseline during the follow-up period of 6 months. Neither the significant antidepressant effect nor the significant transient decrease in executive and verbal episodic memory tests after ECT could be related to changes in hippocampal volume. No persistent cognitive side effects were observed 1 year after ECT.


The immediate increase in hippocampal volume after ECT is reversible and is not related to clinical or cognitive outcome.

Place, publisher, year, edition, pages
2014. Vol. 129, no 4, 303-311 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-202791DOI: 10.1111/acps.12150ISI: 000332684900006PubMedID: 23745780OAI: oai:DiVA.org:uu-202791DiVA: diva2:633490
Swedish Research Council, 2007-6079Knut and Alice Wallenberg Foundation, 1998.0182
Available from: 2013-06-27 Created: 2013-06-27 Last updated: 2014-04-29Bibliographically approved

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