Dynamics of Hippocampal Neurogenesis in Adult Humans
2013 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 153, no 6, 1219-1227 p.Article in journal (Refereed) Published
Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have func- tional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear- bomb-test-derived 14C in genomic DNA, and we present an integrated model of the cell turnover dy- namics. We found that a large subpopulation of hip- pocampal neurons constituting one-third of the neu- rons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neu- rons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neuro- genesis may contribute to human brain function.
Place, publisher, year, edition, pages
Maryland Heights, MO, USA: Elsevier, 2013. Vol. 153, no 6, 1219-1227 p.
Hippocampas, Neurogenesis, regeneration, cell, Humans
Accelerator Physics and Instrumentation
Research subject Physics with specialization in Biophysics
IdentifiersURN: urn:nbn:se:uu:diva-202792DOI: 10.1016/j.cell.2013.05.002ISI: 000319979200008OAI: oai:DiVA.org:uu-202792DiVA: diva2:633569
FunderSwedish Research Council
De två (2) första författarna delar förstaförfattarskapet.2013-06-272013-06-272013-07-22Bibliographically approved