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Association of plasma neutrophil gelatinase-associated lipocalin (NGAL) with sepsis and acute kidney dysfunction
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
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2013 (English)In: Biomarkers, ISSN 1354-750X, Vol. 18, no 4, 349-356 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is secreted by injured kidney cells as well as by activated neutrophils in response to bacterial infections. We assessed the influence of acute renal dysfunction on the association between plasma NGAL and sepsis. Methods: NGAL was measured daily in 138 critically ill patients. Simultaneous recordings of sepsis status and fluctuations in renal function were made. Results: Elevated NGAL was associated with sepsis independent of level of acute renal dysfunction. A cut-off value of 98 ng/mL distinguished sepsis from systemic inflammation with high sensitivity (0.77) and specificity (0.79). Conclusions: Plasma NGAL can help clinicians to identify bacterial infections in critically ill patients.

Place, publisher, year, edition, pages
2013. Vol. 18, no 4, 349-356 p.
Keyword [en]
Acute kidney injury, biomarkers, critical care, CRP, inflammation, PCT
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-202895DOI: 10.3109/1354750X.2013.787460ISI: 000319525700010OAI: oai:DiVA.org:uu-202895DiVA: diva2:634650
Available from: 2013-07-01 Created: 2013-07-01 Last updated: 2013-07-01Bibliographically approved

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