uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Serum lysozyme a surrogate marker of pulmonary microvascular injury in smokers?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
2013 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 33, no 4, 307-312 p.Article in journal (Refereed) Published
Abstract [en]

Progression rate of disease processes in smoke-induced lung injuries varies greatly. Diverse pathophysiological mechanisms may trigger these divergences. The aim of this study was to evaluate whether circulating markers of monocytes/macrophages and/or neutrophil [i.e. lysozyme (LZM) or myeloperoxidase (MPO)] were associated with reduced values of diffusion capacity (DL,CO), which is considered to serve as a mirror of pulmonary microvascular derangement and an early sign of tissue remodelling in smokers. Data obtained from 134 smokers (GOLD stage 1) and 24 matched healthy non-smoking volunteers were evaluated in a cross-sectional study design. Lung function tests as well as single breath test of DL,CO were assessed according to ATS/ERS guidelines. Biomarkers were measured in serum by means of sensitive immunoassays. A subgroup of smokers with normal lung function was created to minimize confounding, by excluding datasets showing significant airflow limitation and abnormally high values of carboxy haemoglobin (COHb), the latter indicating recent smoking. The capacity of serum lysozyme to correctly identify abnormally low values of DL,CO (i.e. <1 center dot 9SD units), tended to be higher than that of Myeloperoxidase as assessed by analyses of receiver operated curves (ROC; AUC 0 center dot 81, 95%CI: 0 center dot 690 center dot 89 versus AUC 0 center dot 67, 95%CI: 0 center dot 600 center dot 81). It is concluded that serum levels of lysozyme, reflecting mainly activated monocytes/macrophages but also neutrophils, were significantly associated with isolated decrements of DL,CO in smokers with normal lung function tests. This suggests monocytes/macrophages to have a significant mechanistic role in early phases of the disease process and/or pulmonary microvascular damage.

Place, publisher, year, edition, pages
2013. Vol. 33, no 4, 307-312 p.
Keyword [en]
biomarkers in serum, diffusion capacity, tobacco smokers
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-202889DOI: 10.1111/cpf.12029ISI: 000319293100010OAI: oai:DiVA.org:uu-202889DiVA: diva2:634681
Available from: 2013-07-01 Created: 2013-07-01 Last updated: 2013-07-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Venge, Per
By organisation
Biochemial structure and function
In the same journal
Clinical Physiology and Functional Imaging
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 184 hits
ReferencesLink to record
Permanent link

Direct link