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Pathophysiology of heparan sulphate: many diseases, few drugs
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2013 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 273, no 6, 555-571 p.Article, review/survey (Refereed) Published
Abstract [en]

Heparan sulphate (HS) polysaccharides are covalently attached to the core proteins of various proteoglycans at cell surfaces and in the extracellular matrix. They are composed of alternating units of hexuronic acid and glucosamine, with sulphate substituents in complex and variable yet cell-specific patterns. Whereas HS is produced by virtually all cells in the body, heparin, a highly sulphated HS variant, is confined to connective-tissue-type mast cells. The polysaccharides interact with a multitude of proteins, mainly through ionic binding, and thereby control key processes in development and homoeostasis. Similar interactions also implicate HS in various pathophysiological settings, including cancer, amyloid diseases, infectious diseases, inflammatory conditions and some developmental disorders. Prospects for the development of HS-based drugs, which are still largely unrealized, are discussed.

Place, publisher, year, edition, pages
2013. Vol. 273, no 6, 555-571 p.
Keyword [en]
amyloid, cancer, heparanase, heparin, inflammation, malaria, sulphation pattern
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-202469DOI: 10.1111/joim.12061ISI: 000318986100003OAI: oai:DiVA.org:uu-202469DiVA: diva2:634844
Available from: 2013-07-01 Created: 2013-06-24 Last updated: 2017-12-06Bibliographically approved

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Lindahl, UlfKjellén, Lena

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