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Reference values for volumetric capnography-derived non-invasive parameters in healthy individuals
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2013 (English)In: Journal of clinical monitoring and computing, ISSN 1387-1307, E-ISSN 1573-2614, Vol. 27, no 3, 281-288 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to determine typical values for non-invasive volumetric capnography (VCap) parameters for healthy volunteers and anesthetized individuals. VCap was obtained by a capnograph connected to the airway opening. We prospectively studied 33 healthy volunteers 32 +/- A 6 years of age weighing 70 +/- A 13 kg at a height of 171 +/- A 11 cm in the supine position. Data from these volunteers were compared with a cohort of similar healthy anesthetized patients ventilated with the following settings: tidal volume (VT) of 6-8 mL/kg, respiratory rate 10-15 bpm, PEEP of 5-6 cmH(2)O and FiO(2) of 0.5. Volunteers showed better clearance of CO2 compared to anesthetized patients as indicated by (median and interquartile range): (1) an increased elimination of CO2 per mL of VT of 0.028 (0.005) in volunteers versus 0.023 (0.003) in anesthetized patients, p < 0.05; (2) a lower normalized slope of phase III of 0.26 (0.17) in volunteers versus 0.39 (0.38) in anesthetized patients, p < 0.05; and (3) a lower Bohr dead space ratio of 0.23 (0.05) in volunteers versus 0.28 (0.05) in anesthetized patients, p < 0.05. This study presents reference values for non-invasive volumetric capnography-derived parameters in healthy individuals. Mechanical ventilation and anesthesia altered these values significantly.

Place, publisher, year, edition, pages
2013. Vol. 27, no 3, 281-288 p.
Keyword [en]
Volumetric capnography, CO2, Dead space, Slope of phase III, Mechanical ventilation
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-203276DOI: 10.1007/s10877-013-9433-xISI: 000319070600011OAI: oai:DiVA.org:uu-203276DiVA: diva2:636257
Available from: 2013-07-09 Created: 2013-07-08 Last updated: 2013-07-09Bibliographically approved

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Suarez-Sipmann, Fernando
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Hedenstierna laboratory
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