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Fullerenes toxicity and electronic properties
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational and Systems Biology.
2013 (English)In: Environmental Chemistry Letters, ISSN 1610-3653, E-ISSN 1610-3661, Vol. 11, no 2, 105-118 p.Article, review/survey (Refereed) Published
Abstract [en]

Nanotechnology globally represents a new direction within scientific development, where the atomic and electronic properties of molecules are used in a unique fashion to produce and construct new and exotic materials and products. Fullerenes (Bucky balls, C-60) constitute a particular group within the field of nanotechnology. Fullerenes find applications in medicine, industrial chemistry and electronics. However, there are several unanswered questions about fullerenes and their toxicological properties. Most toxicological studies on fullerenes evolve around the in vitro and in vivo aspects of pristine C-60 along with chemically modified C-60 molecules. We reviewed toxicology reports on C-60. We bring a critical and challenging evaluation of the electronic and quantum properties of C-60 molecules in context with the implications on cellular factors and metabolites. The evaluation shows that the reactivity and quantum chemical properties of C-60 can have unexpected effects in the cell, by principally absorbing metabolites, such as OH- and H+ ions and alter its reactivity. We thus challenge the present view of C-60 solely based on empirical studies, based on the electronic properties of C-60 that vary considerably with their size and reaction path. A further example of this is the absorption of divalent zinc ions, which shows an increase in reactivity of the C-60 that presents an important pattern of chemical state, reactivity and toxicological potential. The results evaluate the toxicological potential of C-60 from a different angle than conventional, by applying a blend of critical review of the findings on C-60 toxicity, their chemical and electronic properties.

Place, publisher, year, edition, pages
2013. Vol. 11, no 2, 105-118 p.
Keyword [en]
Fullerenes, Chemical modifications, Toxicity prediction, Electronic properties Quantum chemistry, Mutagenicity
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-203413DOI: 10.1007/s10311-012-0387-xISI: 000319348700001OAI: oai:DiVA.org:uu-203413DiVA: diva2:636481
Available from: 2013-07-10 Created: 2013-07-10 Last updated: 2013-07-10Bibliographically approved

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van der Spoel, David
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