Serum Folate and B12 Levels in Association With Cognitive Impairment Among Seniors: Results From the VELESTINO Study in Greece and Meta-Analysis
2013 (English)In: Journal of Aging and Health, ISSN 0898-2643, E-ISSN 1552-6887, Vol. 25, no 4, 589-616 p.Article in journal (Refereed) Published
Objective: To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( > 65 years) residing in Velestino, Greece. Method: Serum measurements and Mini-Mental State Examination (MMSE) assessments were available for 593 Velestinians. In addition, 12 studies availing data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were identified following a search algorithm; pooled effect estimates were derived. Results: Cognitive impairment (MMSE < 24) among Velestenians was associated with lower education level in both genders; decreased social activity, depressive symptoms and low folate levels in males; older age in females. Meta-analyses showed an adverse effect of low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40). Discussion: Low folate levels are associated with cognitive impairment of seniors; underlying pathophysiological mechanisms should be further explored.
Place, publisher, year, edition, pages
2013. Vol. 25, no 4, 589-616 p.
folate, B12, cognitive impairment, meta-analysis, aged
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-203545DOI: 10.1177/0898264313482488ISI: 000320159600004OAI: oai:DiVA.org:uu-203545DiVA: diva2:637134