uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Serum Folate and B12 Levels in Association With Cognitive Impairment Among Seniors: Results From the VELESTINO Study in Greece and Meta-Analysis
Show others and affiliations
2013 (English)In: Journal of Aging and Health, ISSN 0898-2643, E-ISSN 1552-6887, Vol. 25, no 4, 589-616 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( > 65 years) residing in Velestino, Greece. Method: Serum measurements and Mini-Mental State Examination (MMSE) assessments were available for 593 Velestinians. In addition, 12 studies availing data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were identified following a search algorithm; pooled effect estimates were derived. Results: Cognitive impairment (MMSE < 24) among Velestenians was associated with lower education level in both genders; decreased social activity, depressive symptoms and low folate levels in males; older age in females. Meta-analyses showed an adverse effect of low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40). Discussion: Low folate levels are associated with cognitive impairment of seniors; underlying pathophysiological mechanisms should be further explored.

Place, publisher, year, edition, pages
2013. Vol. 25, no 4, 589-616 p.
Keyword [en]
folate, B12, cognitive impairment, meta-analysis, aged
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-203545DOI: 10.1177/0898264313482488ISI: 000320159600004OAI: oai:DiVA.org:uu-203545DiVA: diva2:637134
Available from: 2013-07-16 Created: 2013-07-15 Last updated: 2013-07-16Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Papadopoulos, Fotios C.
By organisation
Psychiatry, University Hospital
In the same journal
Journal of Aging and Health
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 165 hits
ReferencesLink to record
Permanent link

Direct link