uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Fatherhood status and risk of prostate cancer: Nationwide, population-based case-control study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Show others and affiliations
2013 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 133, no 4, 937-943 p.Article in journal (Refereed) Published
Abstract [en]

Previous studies have shown a decreased risk of prostate cancer for childless men; however, the cause of the association remains to be elucidated. The aim of our study was to assess the risk of prostate cancer by fatherhood status, also considering potential confounding factors. In a case-control study in Prostate Cancer data Base Sweden 2.0, a nationwide, population-based cohort, data on number of children, marital status, education, comorbidity and tumor characteristics obtained through nationwide healthcare registers and demographic databases for 117,328 prostate cancer cases and 562,644 controls, matched on birth year and county of residence, were analyzed. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for prostate cancer overall and by risk category, adjusting for marital status and education. Childless men had a decreased risk of prostate cancer compared to fathers, OR=0.83 (95% CI=0.82-0.84), and risk was lower for low-risk prostate cancer, OR=0.74 (95% CI=0.72-0.77), than for metastatic prostate cancer, OR=0.93 (95% CI=0.90-0.97). Adjustment for marital status and education attenuated the association in the low-risk category, adjusted OR=0.87 (95% CI=0.84-0.91), whereas OR for metastatic cancer remained virtually unchanged, adjusted OR=0.92 (95% CI=0.88-0.96). Our data indicate that the association between fatherhood status and prostate cancer to a large part is due to socioeconomic factors influencing healthcare-seeking behavior including testing of prostate-specific antigen levels.

Place, publisher, year, edition, pages
2013. Vol. 133, no 4, 937-943 p.
Keyword [en]
prostate cancer, epidemiology, case-control studies, hypogonadism, androgens
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-203512DOI: 10.1002/ijc.28057ISI: 000320194400017OAI: oai:DiVA.org:uu-203512DiVA: diva2:637278
Available from: 2013-07-17 Created: 2013-07-15 Last updated: 2013-07-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Garmo, Hans G.
By organisation
UCR-Uppsala Clinical Research Center
In the same journal
International Journal of Cancer
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 141 hits
ReferencesLink to record
Permanent link

Direct link