uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Serotonin transporter genotype by environment: Studies on alcohol use and misuse in non-human and human primates
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
Show others and affiliations
2013 (English)In: Translational Neuroscience, ISSN 2081-3856, Vol. 4, no 2, 241-250 p.Article, review/survey (Refereed) Published
Abstract [en]

Much evidence indicates that gene-by-environment interactions (GxE) play a role in alcohol misuse. It has been proposed that interactions between serotonin and stress confer vulnerability for alcohol misuse. The present review examined studies of the interaction between the serotonin transporter linked polymorphic region (5-HTTLPR) genotype and stressful life events and alcohol-related phenotypes, in rhesus monkeys and humans. Ten studies were found that had investigated the interaction of 5-HTTLPR and various measures of stress and alcohol use or misuse, two studies of rhesus monkeys, and eight of humans. The results are contradictory. Important differences were reported in study samples, experimental designs, measures used to assess environmental variables, definitions and measurements of alcohol-related phenotypes, and in the statistical analyses. These differences may explain the contradictory results. Guidelines for future studies are suggested. Results are discussed in light of findings from molecular, non-human animal, and clinical studies. The review highlights the need for future studies examining associations of interactions between the serotonin transporter gene and environmental factors and alcohol misuse, especially in samples followed over time.

Place, publisher, year, edition, pages
2013. Vol. 4, no 2, 241-250 p.
Keyword [en]
Alcohol, Alcohol use disorder, Association, Environment, Gene, Genotype, Interaction, Primates, Serotonin transporter, 5-HTTLPR
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-203720DOI: 10.2478/s13380-013-0121-6ISI: 000320338200009OAI: oai:DiVA.org:uu-203720DiVA: diva2:637563
Available from: 2013-07-19 Created: 2013-07-18 Last updated: 2015-02-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Todkar, AniruddhaNilsson, Kent W.Oreland, LarsComasco, Erika

Search in DiVA

By author/editor
Todkar, AniruddhaNilsson, Kent W.Oreland, LarsComasco, Erika
By organisation
Neuro-psycho-pharmacologyCentre for Clinical Research, County of Västmanland
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 636 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf