uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Show others and affiliations
2015 (English)In: Frontiers in Cellular Neuroscience, ISSN 1662-5102, E-ISSN 1662-5102, Vol. 9, 187Article in journal (Refereed) Published
Abstract [en]

The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle. We compared the levels of prodynorphin (PDYN) and proenkephalin (PENK) mRNAs (by qRT-PCR), and dynorphins and enkephalins (by radioimmunoassay) in the caudate nucleus and putamen between alcoholics and control subjects. We also evaluated whether PDYN promoter variant rs1997794 associated with alcoholism affects PDYN expression. Postmortem specimens obtained from 24 alcoholics and 26 controls were included in final statistical analysis. PDYN mRNA and Met-enkephalin-Arg-Phe, a marker of PENK were downregulated in the caudate of alcoholics, while PDYN mRNA and Leu-enkephalin-Arg, a marker of PDYN were decreased in the putamen of alcoholics carrying high risk rs1997794 C allele. Downregulation of opioid peptides in the dorsal striatum may contribute to development of alcoholism including changes in goal directed behavior and formation of a compulsive habit in alcoholics.

Place, publisher, year, edition, pages
2015. Vol. 9, 187
Keyword [en]
Caudate nucleus, putamen, prodynorphin, proenkephalin, alcoholism
National Category
Neurosciences
Research subject
Neuroscience
Identifiers
URN: urn:nbn:se:uu:diva-204055DOI: 10.3389/fncel.2015.00187ISI: 000354804000001PubMedID: 26029055OAI: oai:DiVA.org:uu-204055DiVA: diva2:637693
Funder
Swedish Research Council
Available from: 2013-07-21 Created: 2013-07-21 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

fulltext(959 kB)55 downloads
File information
File name FULLTEXT01.pdfFile size 959 kBChecksum SHA-512
c0cf0afa4147034e04aef2f663d53cad358e5abcac9bcf5d5a5d88ff21b1b8c5811a58350c9decec5074518a17eca48da0e7ad4b316ebcd0eb99b5d018aeb53e
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Sarkisyan, DaniilHussain, Muhammad ZubairWatanabe, HiroyukiKononenko, OlgaBazov, IgorZhou, XingwuYakovleva, TatianaBakalkin, Georgy

Search in DiVA

By author/editor
Sarkisyan, DaniilHussain, Muhammad ZubairWatanabe, HiroyukiKononenko, OlgaBazov, IgorZhou, XingwuYakovleva, TatianaBakalkin, Georgy
By organisation
Department of Pharmaceutical BiosciencesFunctional Pharmacology
In the same journal
Frontiers in Cellular Neuroscience
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 55 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 478 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf