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Snail and Slug, key regulators of TGF-beta-induced EMT, are sufficient for the induction of single-cell invasion
Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Institute of Biology, Leiden University, Leiden, The Netherlands.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
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2013 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 435, no 1, 58-63 p.Article in journal (Refereed) Published
Abstract [en]

TGF-beta plays a dual role in cancer; in early stages it inhibits tumor growth, whereas later it promotes invasion and metastasis. TGF-beta is thought to be pro-invasive by inducing epithelial-to-mesenchymal transition (EMT) via induction of transcriptional repressors, including Slug and Snail. In this study, we investigated the role of Snail and Slug in TGF-beta-induced invasion in an in vitro invasion assay and in an embryonic zebrafish xenograft model. Ectopic expression of Slug or Snail promoted invasion of single, rounded amoeboid cells in vitro. In an embryonic zebrafish xenograft model, forced expression of Slug and Snail promoted single cell invasion and metastasis. Slug and Snail are sufficient for the induction of single-cell invasion in an in vitro invasion assay and in an embryonic zebrafish xenograft model.

Place, publisher, year, edition, pages
2013. Vol. 435, no 1, 58-63 p.
Keyword [en]
TGF-beta, Single cell invasion, EMT, Slug, Snail
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-204129DOI: 10.1016/j.bbrc.2013.04.037ISI: 000320012900010OAI: oai:DiVA.org:uu-204129DiVA: diva2:637742
Available from: 2013-07-22 Created: 2013-07-22 Last updated: 2017-12-06Bibliographically approved

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