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IgA deficiency in wolves
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Chemical Biology.
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2013 (English)In: Developmental and Comparative Immunology, ISSN 0145-305X, E-ISSN 1879-0089, Vol. 40, no 2, 180-184 p.Article in journal (Refereed) Published
Abstract [en]

Low mean concentrations of serum immunoglobulin A (IgA) and an increased frequency of overt IgA deficiency (IgAD) in certain dog breeds raises the question whether it is a breeding-enriched phenomenon or a legacy from the dog's ancestor, the gray wolf (Canis lupus). The IgA concentration in 99 serum samples from 58 free-ranging and 13 captive Scandinavian wolves, was therefore measured by capture ELISA. The concentrations were markedly lower in the wolf serum samples than in the dog controls. Potential differences in the IgA molecule between dogs and wolves were addressed by sequencing the wolf IgA heavy chain constant region encoding gene (IGHA). Complete amino acid sequence homology was found. Detection of wolf and dog IgA was ascertained by showing identity using double immunodiffusion. We suggest that the vast majority of wolves, the ancestor of the dog, are IgA deficient.

Place, publisher, year, edition, pages
2013. Vol. 40, no 2, 180-184 p.
Keyword [en]
Serum IgA concentrations, IgA deficiency, Dog, Wolf
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-204119DOI: 10.1016/j.dci.2013.01.005ISI: 000320491100011OAI: oai:DiVA.org:uu-204119DiVA: diva2:637769
Available from: 2013-07-22 Created: 2013-07-22 Last updated: 2014-09-22Bibliographically approved

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Hellman, LarsTengvall, KatarinaLindblad-Toh, Kerstin
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Chemical BiologyDepartment of Medical Biochemistry and Microbiology
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