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Methadone in healthy goats: Pharmacokinetics, behaviour and blood pressure
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
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2013 (English)In: Research in Veterinary Science, ISSN 0034-5288, Vol. 95, no 1, 231-237 p.Article in journal (Refereed) Published
Abstract [en]

The pharmacokinetics and effects of the opioid methadone on behaviour, arterial blood pressure, heart rate and haematocrit were studied in goats. Two goats received methadone (0.2 mg/kg) intravenously and the terminal half-life was 88 and 91 min, the volume of distribution 8.4 and 6.1 L/kg, and clearance 86 and 123 mL/min/kg. In a crossover study eight goats received methadone (0.6 mg/kg) or 0.15 M NaCl subcutaneously (SC). After SC administration bioavailability was complete and the terminal half-life was 215 +/- 84 min (mean +/- SD), T-max 31 +/- 15 min and C-max 45 +/- 11 ng/mL. Blood pressure and haematocrit increased while heart rate did not change. The goats did not ruminate and they climbed, scratched, gnawed and showed tail-flicking after SC methadone in contrast to NaCl administration. The use of methadone in goats may be restricted due to the inhibition of rumination and the rather short half-life.

Place, publisher, year, edition, pages
2013. Vol. 95, no 1, 231-237 p.
Keyword [en]
Heart rate, Haematocrit, PK/PD, Opioids, Ruminate
National Category
Natural Sciences
URN: urn:nbn:se:uu:diva-204088DOI: 10.1016/j.rvsc.2013.02.013ISI: 000320289600036OAI: oai:DiVA.org:uu-204088DiVA: diva2:637870
Available from: 2013-07-23 Created: 2013-07-22 Last updated: 2013-07-23Bibliographically approved

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