uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Consensus Recommendations on Pathologic Changes in the Hippocampus: A Postmortem Multicenter Inter-Rater Study
Show others and affiliations
2013 (English)In: Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, E-ISSN 1554-6578, Vol. 72, no 6, 452-461 p.Article in journal (Refereed) Published
Abstract [en]

There is no consensus on the pathologic conditions or severity implied by the term "hippocampal sclerosis" (HS). In this study, a panel of experienced neuropathologists evaluated inter-rater agreement for pathologic diagnoses in the hippocampus and proposes consensus recommendations on the use of the term "HS." In a group of 251 cases of HS selected from a large autopsy cohort (1,388; 18%), a coordinating group identified 5 patterns of degenerative or vascular pathology. Four independent neuropathologists assessed a single set of hematoxylin and eosin-stained sections following descriptive definitions to classify the appearances and assign the diagnosis of HS, if appropriate. Diagnostic agreement (range, 36%-70%) was highest for vascular lesions. Subsequent joint review of all cases highlighted the need to identify neurodegenerative lesions using immunohistochemistry. Initial agreement in assigning the diagnosis of HS varied from 0% to 86%. After a joint review, the group recommended that the term "HS" should be applied to all cases with complete/near-complete neuronal loss and gliosis in the subfields of the cornu Ammonis but not to hippocampal microinfarction. Therefore, the etiology of HS must be defined in association with a neurodegenerative process or as "lacking neurodegenerative markers," a pathologic condition presumed to arise from hypoxic/ischemic mechanisms.

Place, publisher, year, edition, pages
2013. Vol. 72, no 6, 452-461 p.
Keyword [en]
Hippocampal sclerosis, Hippocampus, Postmortem, Immunohistochemistry, Inter-rater study
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-204290DOI: 10.1097/NEN.0b013e318292492aISI: 000319454400001OAI: oai:DiVA.org:uu-204290DiVA: diva2:638345
Available from: 2013-07-30 Created: 2013-07-29 Last updated: 2013-07-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Alafuzoff, Irina
By organisation
Molecular and Morphological Pathology
In the same journal
Journal of Neuropathology and Experimental Neurology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 266 hits
ReferencesLink to record
Permanent link

Direct link