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GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
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2013 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 340, no 6139, 1467-1471 p.Article in journal (Refereed) Published
Abstract [en]

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R-2 approximate to 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for approximate to 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

Place, publisher, year, edition, pages
2013. Vol. 340, no 6139, 1467-1471 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-204277DOI: 10.1126/science.1235488ISI: 000320647000046OAI: oai:DiVA.org:uu-204277DiVA: diva2:638382
Available from: 2013-07-30 Created: 2013-07-29 Last updated: 2016-01-25Bibliographically approved

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Hägg, SaraIngelsson, Erik
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Department of Medical SciencesScience for Life Laboratory, SciLifeLab
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