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Deign and implementation of an imprinted material for the exaction of the endocrine disruptor bisphenol A from milk
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
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2013 (English)In: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 931, 164-169 p.Article in journal (Refereed) Published
Abstract [en]

This paper describes the determination of bisphenol A (BPA) in milk samples, using a novel molecularly imprinted polymer. The imprinted polymer was developed using a rational design approach, and pre-polymerization interactions were investigated using molecular dynamics simulations and X-ray crystallography. A hydroquinone-imprinted polymer was used for solid phase extraction (SPE) clean-up of samples. BPA was quantified by high performance liquid chromatography (HPLC) and fluorescence (FLD) detection. Following validation, the method described was capable of determining bisphenol A in milk down to a limit of detection of 1.32 mu g kg(-1). The method was applied to a survey (n = 27) of commercial milk products; BPA was detected in one of the samples, at a level of 176 mu g kg(-1). Test results were confirmed by a parallel UHPLC-MS/MS analytical method. This demonstrates the utility of the hydroquinone-imprinted polymer for application to selective sample clean-up and analysis of bisphenol A in milk, avoiding possible detrimental affects associated with template bleeding and without the need for expensive or difficult-to-obtain template. 

Place, publisher, year, edition, pages
2013. Vol. 931, 164-169 p.
Keyword [en]
MIP, Bisphenol A, SPE, Milk, UHPLC-MS/MS, HPLC-FLD
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-204856DOI: 10.1016/j.jchromb.2013.05.025ISI: 000321593900023OAI: oai:DiVA.org:uu-204856DiVA: diva2:640131
Available from: 2013-08-12 Created: 2013-08-12 Last updated: 2017-12-06Bibliographically approved

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