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Short-and long-term individual variation in NT-proBNP levels in patients with stable coronary artery disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
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2013 (English)In: Clinica Chimica Acta, ISSN 0009-8981, E-ISSN 1873-3492, Vol. 422, 15-20 p.Article in journal (Refereed) Published
Abstract [en]

Background: In addition to diagnosis of heart failure (HF) natriuretic peptides (BNP and NT-proBNP) may be used for risk prediction in stable and acute coronary artery disease. The aim of the study was to evaluate the short- and long-term individual variation of NT-proBNP in patients with stable coronary artery disease. Methods: Twenty-four patients with suspected stable coronary artery disease and scheduled for elective coronary angiography were included. Blood samples were drawn at enrolment and, on average 3 weeks later, serially the day prior to coronary angiography. NT-proBNP was determined using Elecsys proBNP sandwich immunoassay (Roche Diagnostics). Results: The individual variation in NT-proBNP over 4 h was 11.8%, over 20 h 12.4% and over 3 weeks 20.4%. The corresponding positive and negative lognormal reference change values (RCV) were +41/-29%, +42/-30% and + 76/-43%, respectively. No significant circadian variation was found. Conclusions: Our results suggest that an increase in NT-proBNP levels of >42% or a decrease of >30% is needed to indicate a reliable short-term change; and for a long-term change an increase of >76% or a decrease of >43% is required. This should be considered when interpreting changes in NT-proBNP levels. 

Place, publisher, year, edition, pages
2013. Vol. 422, 15-20 p.
Keyword [en]
NT-proBNP, Cardiovascular diseases/diagnosis, Individual variation, Reference change values, Immunoassay
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-204798DOI: 10.1016/j.cca.2013.03.025ISI: 000320894400004OAI: oai:DiVA.org:uu-204798DiVA: diva2:641070
Available from: 2013-08-15 Created: 2013-08-12 Last updated: 2017-12-06Bibliographically approved

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Ahlström, HåkanEggers, Kai M.Venge, PerLindahl, Bertil

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