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Psychosocial Stress Related to the Loss of a Close Relative the Year Before or During Pregnancy and Risk of Preeclampsia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
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2013 (English)In: Hypertension, ISSN 0194-911X, E-ISSN 1524-4563, Vol. 62, no 1, 183-189 p.Article in journal (Refereed) Published
Abstract [en]

The role of stress in the pathogenesis of preeclampsia has only been investigated in a few studies, and the findings are not conclusive. We analyzed whether maternal bereavement shortly before or during pregnancy is associated with an increased risk of preeclampsia. We conducted a cohort study of singleton births in Denmark during 1978-2008 and in Sweden during 1973-2006 (n=4 122 490) by linking national population-based registers. Mothers were considered exposed to bereavement if they lost a parent, a sibling, a partner, or a child the year before or during pregnancy (n=124 553). The risk of preeclampsia was slightly increased for women who lost a close relative during the 6 months before conception (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.06-1.23) or during the first trimester of pregnancy (OR, 1.15; 95% CI, 1.03-1.29). Exposure during these periods tended to be more closely related to early preeclampsia (delivery before 34 weeks of gestation; OR, 1.37; 95% CI, 1.12-1.67) than to late preeclampsia (OR, 1.13; 95% CI, 1.06-1.20). The strongest association was observed between loss of a child and early preeclampsia when the exposure window was from 6 months before pregnancy until start of second trimester (OR, 4.03; 95% CI, 2.46-6.61). Our results related to timing of exposure suggest that severe stress may influence early placentation. However, the public health implications of our findings are limited in populations with a low prevalence of severe stress exposures.

Place, publisher, year, edition, pages
2013. Vol. 62, no 1, 183-189 p.
Keyword [en]
bereavement, cohort study, placentation, preeclampsia, psychological stress
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-204788DOI: 10.1161/HYPERTENSIONAHA.111.00550ISI: 000320302600032OAI: oai:DiVA.org:uu-204788DiVA: diva2:641092
Available from: 2013-08-15 Created: 2013-08-12 Last updated: 2013-08-15Bibliographically approved

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