Osteomalaci på grund av tumörorsakad fosfatbrist: Fokus på FGF23 i fysiologi och klinik
2012 (Swedish)In: Läkartidningen, ISSN 0023-7205, Vol. 109, no 32-33, 1414-1416 p.Article in journal (Other academic) Published
Oncogenic osteomalacia is a rare syndrome caused by a small tumor, of mesenchymal origin, that produces FGF23. FGF23 is a recently described bone derived factor closely regulated by calcitriol and phosphate load. In a feedback loop it increases renal phosphate loss and decreases calcitriol activation. Unregulated production of FGF23 by a tumor causes negative phosphate balance and deficient mineralization of the skeleton, with pain and fractures as a consequence. We have used determination of a venous gradient of FGF23 as an aid in localizing FGF23 producing tumors in 10 cases. In eight cases the tumor has been removed, one patient awaits further examination and in one case it has not been possible to localize the tumor.
Place, publisher, year, edition, pages
2012. Vol. 109, no 32-33, 1414-1416 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-205356PubMedID: 22953430OAI: oai:DiVA.org:uu-205356DiVA: diva2:641280