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Predictors of time to relapse/recurrence after electroconvulsive therapy in patients with major depressive disorder: a population-based cohort study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
2011 (English)In: Depression Research and Treatment, ISSN 2090-1321, E-ISSN 2090-133X, Vol. 2011, Art. id:470985- p.Article in journal (Refereed) Published
Abstract [en]


The aim of the study is to define predictors of relapse/recurrence after electroconvulsive therapy, ECT, for patients with major depressive disorder.


A study of all patients (n = 486) treated by means of ECT for major depressive disorder was performed. The data were derived from a regional quality register in Sweden. Psychiatric hospitalisation or suicide was used as a marker for relapse/recurrence.


The relapse/recurrence rate within one year after ECT was 34%. Factors associated with increased risk of relapse/recurrence included comorbid substance dependence and treatment with benzodiazepines or antipsychotics during the follow-up period.


Within the first years after ECT, relapses/recurrences leading to hospitalisation or suicide are common. Treatment with lithium might be beneficial, while benzodiazepines, antipsychotics, or continuation ECT does not seem to significantly reduce the risk of relapse/recurrence.

Place, publisher, year, edition, pages
2011. Vol. 2011, Art. id:470985- p.
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URN: urn:nbn:se:uu:diva-205420DOI: 10.1155/2011/470985PubMedID: 22110913OAI: oai:DiVA.org:uu-205420DiVA: diva2:641393
Available from: 2013-08-16 Created: 2013-08-16 Last updated: 2013-08-16Bibliographically approved

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