Acute sleep deprivation delays the glucagon-like peptide 1 peak response to breakfast in healthy men
2013 (English)In: Nutrition & Diabetes, ISSN 2044-4052, Vol. 3, e78- p.Article in journal (Refereed) Published
OBJECTIVE: Previous experiments have demonstrated that acute sleep loss impairs glucose homeostasis and increases food intake in humans. The incretin hormone glucagon-like peptide 1 (GLP-1) enhances postprandial insulin secretion and promotes satiety. Hypothesizing that the detrimental metabolic effects of sleep curtailment imply alterations in GLP-1 signaling, we investigated 24-h serum total GLP-1 concentrations during total sleep deprivation (TSD) and a normal sleep/wake cycle (comprising similar to 8h of sleep) in 12 healthy young men. METHODS: Sessions started at 1800 h, and subjects were provided with standardized meals. Assessments of serum GLP-1 took place in 1.5- to 3-h intervals, focusing on the response to breakfast intake (3.8 MJ). RESULTS: Across conditions, 24-h concentration profiles of GLP-1 were characterized by the expected postprandial increases (P<0.001). Although there were no differences in magnitude between conditions (P>0.11), the postprandial GLP-1 peak response to breakfast intake was delayed by similar to 90 min following sleep loss in comparison with regular sleep (P<0.02). CONCLUSIONS: Results indicate that acute TSD exerts a mild, but discernible effect on the postprandial dynamics of circulating GLP-1 concentrations in healthy men.
Place, publisher, year, edition, pages
2013. Vol. 3, e78- p.
glucagon-like peptide 1, hormonal regulation, sleep, sleep deprivation
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-205334DOI: 10.1038/nutd.2013.20ISI: 000320923000007OAI: oai:DiVA.org:uu-205334DiVA: diva2:641512