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Modeling yeast osmoadaptation at different levels of resolution
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics. Institutionen för matematiska vetenskaper, Göteborgs universitet.
2013 (English)In: Journal of Bioinformatics and Computational Biology, ISSN 0219-7200, Vol. 11, no 2, 1330001- p.Article, review/survey (Refereed) Published
Abstract [en]

We review the proposed mathematical models of the response to osmotic stress in yeast. These models mainly differ in the choice of mathematical representation (e. g. Bayesian networks, ordinary differential equations, or rule-based models), the extent to which the modeling is data-driven, and predictability. The overview exemplifies how one biological system can be modeled with various modeling techniques and at different levels of resolution, and how the choice typically is based on the amount and quality of available data, prior information of the system, and the research question in focus. As a natural part of the overview, we discuss requirements, advantages, and limitations of the different modeling approaches.

Place, publisher, year, edition, pages
2013. Vol. 11, no 2, 1330001- p.
Keyword [en]
Osmotic stress, yeast, mathematical modeling
National Category
Bioinformatics (Computational Biology)
URN: urn:nbn:se:uu:diva-205470DOI: 10.1142/S0219720013300013ISI: 000321005100004OAI: oai:DiVA.org:uu-205470DiVA: diva2:641539
Available from: 2013-08-17 Created: 2013-08-17 Last updated: 2013-08-17Bibliographically approved

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