uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Effects of cis-9,trans-11 CLA in rats at intake levels reported for breast-fed infants
Show others and affiliations
2006 (English)In: Lipids, ISSN 0024-4201, E-ISSN 1558-9307, Vol. 41, no 7, 669-677 p.Article in journal (Refereed) Published
Abstract [en]

CLA intake in exclusively breast-fed infants is close to levels found to have physiological effects in animals. However, in the majority of studies mixtures of CLA isomers have been used and the independent effects of the major CLA isomer in human milk, cis-9, trans-11 CLA, at the intake level in exclusively breast-fed infants have hardly been studied. We therefore studied the effects of cis-9,trans-11 CLA on plasma lipids and glucose, immune function, and bone metabolism in growing rats. Thirty male Sprague-Dawley rats (n = 10/group) were fed either 20 mg/kg/d cis-9,trans-11 CLA and 20 mg/kg/d sunflower oil (CLA20), 40 mg/kg/d cis-9,trans-11 CLA (CLA40), or 40 mg/kg/d sunflower oil (placebo) for 8 wk. No significant differences between groups were found in plasma lipids, glucose, insulin, C-reactive protein, or lipid peroxidation. Liver fat content was lowest in the CLA20 group. In vitro interleukin 2 (IL-2) production increased, and tumor necrosis factor alpha, IL-1 beta, prostaglandin E-2, and leukotriene 134 production decreased in the CLA20 group. No differences between groups were detected in IL-4, IL-6, or interferon gamma production, plasma osteocalcin, insulin-like growth factor, or urinary deoxypyridinoline crosslinks. Plasma tartrate-resistant acid phosphatase 5b activity was significantly increased in the CLA40 group. The results indicate anti-inflammatory effects and enhanced T-cell function for the CLA20 group. No adverse effects were seen in the CLA20 group, whereas indications of increased bone resorption rate were observed in the CLA40 group.

Place, publisher, year, edition, pages
2006. Vol. 41, no 7, 669-677 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-36292DOI: 10.1007/s11745-006-5018-5ISI: 000241071300006PubMedID: 17069351OAI: oai:DiVA.org:uu-36292DiVA: diva2:64191
Available from: 2007-07-09 Created: 2007-07-09 Last updated: 2011-05-31Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Basu, Samar
By organisation
Department of Public Health and Caring Sciences
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 157 hits
ReferencesLink to record
Permanent link

Direct link