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Evolution of voltage-gated sodium channels
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. (Pharmacology)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. (Pharmacology)
2013 (English)Other (Refereed)
Abstract [en]

Voltage-gated sodium channels play important roles in the nervous system by enabling propagation of action potentials along axons. It has been suggested that sodium channels evolved from calcium channels before the split of animals and choanoflagellates, as deduced from studies of sequence motifs important in the ion selectivity of sodium and calcium channels. The sodium channel alpha gene was subsequently duplicated in the two whole-genome duplication events (2R) in early vertebrate evolution, resulting in four genes. Several local duplication events in tetrapods later resulted in the total set of ten sodium channel a genes present in today’s humans. In teleosts, another whole-genome duplication event (3R) doubled the ancestral vertebrate set from four to eight. The high number of sodium channel gene duplicates in both tetrapods and teleosts probably reflects their great importance in the evolution of the vertebrate nervous system. 

Place, publisher, year, pages
John Wiley & Sons, 2013.
National Category
Natural Sciences
Research subject
Biology
Identifiers
URN: urn:nbn:se:uu:diva-205603OAI: oai:DiVA.org:uu-205603DiVA: diva2:642167
Note

Article written for the web-based Encyclopedia of Life Sciences (eLS).

Available from: 2013-08-20 Created: 2013-08-20 Last updated: 2013-08-20

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http://www.els.net/WileyCDA/ElsArticle/refId-a0024936.html
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