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Novel magnesium phosphate cements with high early strength and antibacterial properties
Technical University of Catalonia. (Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering)ORCID iD: 0000-0001-7462-4236
Technical University of Catalonia. (Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering)
2011 (English)In: Acta Biomaterialia, ISSN 1742-7061, Vol. 7, 1853-1861 p.Article in journal (Refereed) Published
Abstract [en]

Magnesium phosphate cements (MPCs) have been extensively used as fast setting repair cements in civil engineering. They have properties that are also relevant to biomedical applications, such as fast setting, early strength acquisition and adhesive properties. However, there are some aspects that should be improved before they can be used in the human body, namely their highly exothermic setting reaction and the release of potentially harmful ammonia or ammonium ions. In this paper a new family of MPCs was explored as candidate biomaterials for hard tissue applications. The cements were prepared by mixing magnesium oxide (MgO) with either sodium dihydrogen phosphate (NaH2PO4) or ammonium dihydrogenphosphate (NH4H2PO4), or an equimolar mixture of both. The exothermia and setting kinetics of the new cement formulations were tailored to comply with clinical requirements by adjusting the granularity of the phosphate salt and by using sodium borate as a retardant. The ammonium-containing MPC resulted in struvite (MgNH4PO46H2O) as the major reaction product, whereas the MPC prepared with sodium dihydrogenphosphate resulted in an amorphous product. Unreacted magnesium oxide was found in all the formulations.The MPCs studied showed early compressive strengths substantially higher than that of apatitic calcium phosphate cements. The Na-containing MPCs were shown to have antibacterial activity against Streptococcus sanguinis, which was attributed to the alkaline pH developed during the setting reaction.

Place, publisher, year, edition, pages
2011. Vol. 7, 1853-1861 p.
Keyword [en]
Magnesium phosphate cement, Dental cement, Bone cement, Antibacterial properties, struvite
National Category
Medical and Health Sciences Natural Sciences
Research subject
Biomedical Laboratory Science
URN: urn:nbn:se:uu:diva-206071DOI: 10.1016/j.actbio.2010.12.008ISI: 000288971300047OAI: oai:DiVA.org:uu-206071DiVA: diva2:643375
Available from: 2013-08-27 Created: 2013-08-27 Last updated: 2015-02-25Bibliographically approved

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