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Nanomedicine strategies for drug delivery to the ear
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
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2013 (English)In: Nanomedicine, ISSN 1743-5889, E-ISSN 1748-6963, Vol. 8, no 7, 1155-1172 p.Article, review/survey (Refereed) Published
Abstract [en]

The highly compartmentalized anatomy of the ear aggravates drug delivery, which is used to combat hearing-related diseases. Novel nanosized drug vehicles are thought to overcome the limitations of classic approaches. In this article, we summarize the nanotechnology-based efforts involving nano-objects, such as liposomes, polymersomes, lipidic nanocapsules and poly( lactic-co-glycolic acid) nanoparticles, as well as nanocoatings of implants to provide an efficient means for drug transfer in the ear. Modern strategies do not only enhance drug delivery efficiency, in the inner ear these vector systems also aim for specific uptake into hair cells and spiral ganglion neurons. These novel peptide-mediated strategies for specific delivery are reviewed in this article. Finally, the biosafety of these vector systems is still an outstanding issue, since long-term application to the ear has not yet been assessed.

Place, publisher, year, edition, pages
2013. Vol. 8, no 7, 1155-1172 p.
Keyword [en]
antibody, cochlea, hearing loss, inner ear, local therapy, nanotechnology-mediated drug delivery, peptide ligand n round window membrane, specific targeting, surface functionalization
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-206397DOI: 10.2217/NNM.13.104ISI: 000320853500018OAI: oai:DiVA.org:uu-206397DiVA: diva2:644530
Available from: 2013-08-30 Created: 2013-08-30 Last updated: 2017-12-06Bibliographically approved

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Rask-Andersen, Helge

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