Community Diarrhea Incidence Before and After Rotavirus Vaccine Introduction in Nicaragua
2013 (English)In: American Journal of Tropical Medicine and Hygiene, ISSN 0002-9637, Vol. 89, no 2, 246-250 p.Article in journal (Refereed) Published
We estimated the incidence of watery diarrhea in the community before and after introduction of the pentavalent rotavirus vaccine in Leon, Nicaragua. A random sample of households was selected before and after rotavirus vaccine introduction. All children < 5 years of age in selected households were eligible for inclusion. Children were followed every 2 weeks for watery diarrhea episodes. The incidence rate was estimated as numbers of episodes per 100 child-years of exposure time. A mixed effects Poisson regression model was fit to compare incidence rates in the pre-vaccine and vaccine periods. The pre-vaccine cohort (N = 726) experienced 36 episodes per 100 child-years, and the vaccine cohort (N = 826) experienced 25 episodes per 100 child-years. The adjusted incidence rate ratio was 0.60 (95% confidence interval [CI] 0.40, 0.91) during the vaccine period versus the pre-vaccine period, indicating a lower incidence of watery diarrhea in the community during the vaccine period.
Place, publisher, year, edition, pages
2013. Vol. 89, no 2, 246-250 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-206560DOI: 10.4269/ajtmh.13-0026ISI: 000322683100012OAI: oai:DiVA.org:uu-206560DiVA: diva2:644922