Pandoraviruses: Amoeba Viruses with Genomes Up to 2.5 Mb Reaching That of Parasitic Eukaryotes
2013 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 341, no 6143, 281-286 p.Article in journal (Refereed) Published
Ten years ago, the discovery of Mimivirus, a virus infecting Acanthamoeba, initiated a reappraisal of the upper limits of the viral world, both in terms of particle size (>0.7 micrometers) and genome complexity (>1000 genes), dimensions typical of parasitic bacteria. The diversity of these giant viruses (the Megaviridae) was assessed by sampling a variety of aquatic environments and their associated sediments worldwide. We report the isolation of two giant viruses, one off the coast of central Chile, the other from a freshwater pond near Melbourne (Australia), without morphological or genomic resemblance to any previously defined virus families. Their micrometer-sized ovoid particles contain DNA genomes of at least 2.5 and 1.9 megabases, respectively. These viruses are the first members of the proposed "Pandoravirus" genus, a term reflecting their lack of similarity with previously described microorganisms and the surprises expected from their future study.
Place, publisher, year, edition, pages
2013. Vol. 341, no 6143, 281-286 p.
Medical and Health Sciences Natural Sciences
IdentifiersURN: urn:nbn:se:uu:diva-206441DOI: 10.1126/science.1239181ISI: 000321959300045OAI: oai:DiVA.org:uu-206441DiVA: diva2:644937
De två (2) första författarna delar förstaförfattarskapet.2013-09-022013-08-302013-09-02Bibliographically approved