uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Involvement of heparanase in atherosclerosis and other vessel wall pathologies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Show others and affiliations
2013 (English)In: Matrix Biology, ISSN 0945-053X, E-ISSN 1569-1802, Vol. 32, no 5, 241-251 p.Article, review/survey (Refereed) Published
Abstract [en]

Heparanase, the sole mammalian endoglycosidase degrading heparan sulfate, is causally involved in cancer metastasis, angiogenesis, inflammation and kidney dysfunction. Despite the wide occurrence and impact of heparan sulfate proteoglycans in vascular biology, the significance of heparanase in vessel wall disorders is underestimated. Blood vessels are highly active structures whose morphology rapidly adapts to maintain vascular function under altered systemic and local conditions. In some pathologies (restenosis, thrombosis, atherosclerosis) this normally beneficial adaptation may be detrimental to overall function. Enzymatic dependent and independent effects of heparanase on arterial structure mechanics and repair closely regulate arterial compliance and neointimal proliferation following endovascular stenting. Additionally, heparanase promotes thrombosis after vascular injury and contributes to a pro-coagulant state in human carotid atherosclerosis. Importantly, heparanase is closely associated with development and progression of atherosclerotic plaques, including stable to unstable plaque transition. Consequently, heparanase levels are markedly increased in the plasma of patients with acute myocardial infarction. Noteworthy, heparanase activates macrophages, resulting in marked induction of cytokine expression associated with plaque progression towards vulnerability. Together, heparanase emerges as a regulator of vulnerable lesion development and potential target for therapeutic intervention in atherosclerosis and related vessel wall complications.

Place, publisher, year, edition, pages
2013. Vol. 32, no 5, 241-251 p.
Keyword [en]
Extracellular matrix, Heparan sulfate, Heparanase, Atherosclerosis, Vulnerable plaque, Thrombosis, Stenosis, Inflammation, Macrophages, Colitis, Diabetic nephropathy
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-206747DOI: 10.1016/j.matbio.2013.03.002ISI: 000322298000006OAI: oai:DiVA.org:uu-206747DiVA: diva2:645343
Available from: 2013-09-04 Created: 2013-09-04 Last updated: 2013-09-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Li, Jin-Ping
By organisation
Department of Medical Biochemistry and Microbiology
In the same journal
Matrix Biology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 297 hits
ReferencesLink to record
Permanent link

Direct link