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Molecular consequences of animal breeding
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2013 (English)In: Current Opinion in Genetics and Development, ISSN 0959-437X, E-ISSN 1879-0380, Vol. 23, no 3, 295-301 p.Article in journal (Refereed) Published
Abstract [en]

The phenotypic diversity in domestic animals provides a unique opportunity to study genotype-phenotype relationships. The identification of causal mutations provides an insight into what types of mutations have contributed to phenotypic evolution in domestic animals. Whole genome sequencing has revealed that fixation of null alleles that inactivate genes, which are essential under natural conditions but disadvantageous on the farm, has not been a common mechanism for genetic adaptation in domestic animals. Numerous examples have been revealed where structural changes cause specific phenotypic effects by altering transcriptional regulation. An emerging feature is also the evolution of alleles by the accumulation of several consecutive mutations which affect gene function.

Place, publisher, year, edition, pages
2013. Vol. 23, no 3, 295-301 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-206757DOI: 10.1016/j.gde.2013.02.014ISI: 000321883500010OAI: oai:DiVA.org:uu-206757DiVA: diva2:645404
Available from: 2013-09-04 Created: 2013-09-04 Last updated: 2013-09-04Bibliographically approved

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Andersson, Leif
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Department of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLab
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